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Legal Natural Nootropics In Food PRL - 8 - 53 Nootropics Powder Short Term Memory CAS 51352-88-6

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Legal Natural Nootropics In Food PRL - 8 - 53 Nootropics Powder Short Term Memory CAS 51352-88-6

China Legal Natural Nootropics In Food PRL - 8 - 53 Nootropics Powder Short Term Memory CAS 51352-88-6 supplier
Legal Natural Nootropics In Food PRL - 8 - 53 Nootropics Powder Short Term Memory CAS 51352-88-6 supplier Legal Natural Nootropics In Food PRL - 8 - 53 Nootropics Powder Short Term Memory CAS 51352-88-6 supplier

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Product Details:

Place of Origin: China
Brand Name: Biopro
Certification: GMP/HACCP/ISO
Model Number: NTP-010

Payment & Shipping Terms:

Minimum Order Quantity: 100 Grams
Price: USD1~10 per Gram
Packaging Details: Foil Bag, Drums
Delivery Time: Immediate Shipment
Payment Terms: T/T, Western Union, MoneyGram
Supply Ability: 10 kgs per week
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Detailed Product Description
Product Name: PRL-8-53 CAS No.: 51352-88-6
Other Name: PRL-8-53 Classification: Nootropics
Molecular Weight: 283.36 Molecular Formula: C18H21NO2
Purity: 99% Min. Standard: Pharmaceutical Grade

PRL - 8 - 53 Nootropics Powder Short Term Memory CAS No. 51352-88-6

 

  • Description

    PRL-8-53 is a synthetic Nootropic supplement, meaning it was created in a lab. Its full name is methyl 3-(2-(benzyl(methyl)amino)ethyl)benzoate.

    Researchers found that oral supplementation of PRL-8-53 was able to improve avoidance learning in rats. One human study has also been done on PRL-8-53. Each participant ingested a placebo and PRL-8-53, at separate times, in a double blind crossover study. Participants then took a memory test, consisting of twelve monosyllabic words in a particular order. The test was conducted three times, immediately after supplementation, one day after supplementation, and four days after supplementation.

    People that remembered more than eight words after taking a placebo experienced minor benefits, but people over 30 or with poor short term memory benefitted greatly from supplementation. In some cases, their score on the word test doubled.

    No side effects were observed in the human study, and preliminary rodent evidence suggests PRL-8-53 is safe. Using PRL-8-53 as a dietary supplement, however, cannot be recommended at this time because it is a synthetic substance and all of the evidence for its effects comes from studies funded by the holder of the patent. Though this link should not invalidate the available evidence, independent replication would go a long way toward confirming PRL-8-53’s efficacy.

     
  • Specification

    Product Name: PRL-8-53
    Other Name:
    Methyl 3-(2-(benzyl(methyl)amino)ethyl)benzoate
    CAS #: 15180-02-6
    Purity: 99% min.
    Molecular Formula:
    C18H21NO2
    Molecular Weight: 283.36
    Structure:

    Legal Natural Nootropics In Food PRL - 8 - 53 Nootropics Powder Short Term Memory CAS 51352-88-6
     
  • Purity

    Our 
    PRL-8-53 has a purity not less than 99%.
     
  • Application Information

    PRL-8-53 is a synthetic drug which is currently unscheduled. Apomorphine is a dopamine agonist, and causes compulsive gnawing in rats. Combining PRL-8-53 with apomorphine can be used to assess the dopaminergic effect of PRL-8-53 via change in gnawing behavior. PRL-8-53 at 4mg/kg increased apomorphine-induced gnawing in rats, and was also effective in improving conditioned avoidance learning, indicating that PRL-8-53 is a dopamine agonist.

    Studies in rats have noted an increase in conditioned avoidance learning, with dose-dependent effects in the oral dosing range of 5-20mg/kg.

    Oral ingestion of a single dose of 5mg PRL-8-53 120-150 minutes prior to cognitive testing noted that after a word recollection test (twelve monosyllabic words orally given to participants) that recollection measured 24 hours and 96 hours after testing was increased with PRL-8-53 relative to placebo. Overall improvements in recollection differed based on how many words were recalled under placebo, with the poor performers (six or less words) experiencing a 87.5-105% increase in recollection and the high performers (eight or more words) a 7.9-14% increase which failed to reach statistical significance; when controlling for subjects over the age of 30 only, a 108-152% increase was noted.

    Acquisition rates (immediately after the test) failed to improve overall with PRL-8-53 relative to placebo aside from the subgroup that remembered less than six words under placebo, where a mild 18% increase in acquisition was noted and a 31.4% increase when assessing only persons over the age of 30.

    The lone study in humans conducted by the patent holder has suggested relatively large increases in short term memory with single dose PRL-8-53. This information requires independent replication.

  • Reference List of Available Nootropics:
     
    CAS Product Name Other Name
    135463-81-9 Coluracetam BCI-540
    62613-82-5 Oxiracetam ISF 2522
    72432-10-1 Aniracetam Draganon
    59776-89-5 Piracetam  
    72869-16-0 Pramiracetam CI-879
    157115-85-0 Noopept GVS-111
    15180-02-6 Amfonelic Acid AFA
    314728-85-3 Sunifiram DM-235
    1270138-40-3 NSI-189 NSI189
    51352-87-5 PRL-8-53  
    314728-85-3 Unifiram DM-232
    22503-72-6 IDRA-21  

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