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CAS 106650-56-0 Sibutramine Natural Weight Loss Supplements , 100% Guarantee Content

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CAS 106650-56-0 Sibutramine Natural Weight Loss Supplements , 100% Guarantee Content

China CAS 106650-56-0 Sibutramine Natural Weight Loss Supplements , 100% Guarantee Content supplier

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Product Details:

Place of Origin: China
Brand Name: Biopro
Certification: ISO9001,USP,GMP
Model Number: WLP-03

Payment & Shipping Terms:

Minimum Order Quantity: Negotiation
Price: Negotiation
Packaging Details: Foil bag, disguised discreet package or according to customer needs.
Delivery Time: Within 24hours after payment
Payment Terms: Western Union, MoneyGram, T/T
Supply Ability: Mass in stock
Detailed Product Description
Product Name: Sibutramine Alias: Reductil, Meridia
CAS: 106650-56-0 MF: C17H26ClN
MW: 279.85 Appearance: White Crystal Powder
Purity: 99% Min Usage: Lose Weight And Muscle Gain

CAS 106650-56-0 Sibutramine Natural Weight Loss Supplements , 100% Guarantee Content


Sibutramine was a medication that was primarily used to help overweight individuals lose weight, but was also sometimes prescribed to help people keep the weight off. This drug belonged to a class of medications known as appetite suppressants, which are said to aid in curbing hunger by altering the appetite control centers in the brain.

1. Quick Details:


Product name: Sibutramine
Synonyms: 1-[1-(4-chlorophenyl)cyclobutyl]-n,n,3-trimethyl-butan-1-amine
Alias: Reductil, Meridia
CAS: 106650-56-0
MF: C17H26ClN
MW: 279.85
Assay: 99% min
Water Solubility : 2.9 mg/mL
Appearance: White crystal powder
Grade: Pharmaceutical Grade
Storage: Shading, confined preservation


2. Sibutramine Description:


Sibutramine is a medication that assists with weight-loss by altering neurotransmitters within the brain. Neurotransmitters are chemicals that are produced and released by nerves in order to communicate with other nerves. Released neurotransmitters may attach to other nerves or they may be taken up again by the nerves that release them, a process termed reuptake. Sibutramine blocks the reuptake of the neurotransmitters dopamine, norepinephrine, and serotonin. Blocking the reuptake of neurotransmitters alters the balance of neurotransmitters within the nerve cells and thereby affect nerve function and interaction.


Patients taking sibutramine may achieve a 5-10% reduction from their baseline weight. Additionally, sibutramine-assisted weight loss has been accompanied by improvement in blood lipids (e.g, cholesterol). Sibutramine was approved by the FDA in 1997.


3. Fuction:


Neurotransmitters are chemicals that the nerves of the body create and release in order to communicate with other nerves. Sometimes these released chemicals become attached to other nerves, while at other times they become reattached to the same nerve that released them. Sibutramine worked by preventing these chemicals - which included norepinephrine, serotonin, and dopamine - from reattaching to the same nerves that produced them. This process allowed for an increase of neurotransmitters in the synaptic clefts, which was thought to help decrease hunger in the patient.


Sibutramine is used together with diet and exercise to treat obesity that may be related to diabetes, high cholesterol, or high blood pressure.


4. Mechanism of Action and Effect:


Sibutramine is a serotonin (5-hydroxytryptamine, 5-HT) and norepinephrine (NE) reuptake inhibitor (SNRI).In vitro testing found sibutramine to be much less potent than its primary and secondary amine metabolites in inhibiting monoamine reuptake. Therefore, the pharmacological actions of sibutramine are thought to be due predominantly to its active metabolites. The metabolites of sibutramine inhibit 5-HT and NE reuptake with potencies comparable to those of fluoxetine and desipramine, respectively.


Combined NE and 5-HT reuptake inhibition is thought to promote a sense of satiety, leading to a decrease in energy intake, and, possibly, to increase resting metabolic rate. Randomized, placebo-controlled, double-blind studies in obese and in nonobese subjects have shown significant reductions in self-rated premeal hunger and in energy intake with sibutramine use, even in the absence of an imposed reduced-calorie diet. One study found no difference in the decrease in resting energy expenditure associated with weight loss between subjects receiving sibutramine and subjects receiving placebo, in spite of significantly greater weight loss in the sibutramine group. In another study, basal metabolic rate, as measured by indirect calorimetry, increased more in sibutramine-treated patients than in patients receiving placebo; however, this finding has not been consistent.


5. Sibutramine Dosage:


Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.Sibutramine is usually taken once daily. Follow your doctor's instructions.Your doctor may occasionally change your dose to make sure you get the best results.Sibutramine can be taken with or without food.


You should lose at least 4 pounds during the first 4 weeks of taking sibutramine and eating a low calorie diet. Tell your doctor if you do not lose at least 4 pounds after taking the medication for 4 weeks.Your blood pressure and pulse will need to be checked often. Visit your doctor regularly.Sibutramine should not be taken for longer than 2 years.


6. COA:


Item Standard Test Result
Description white crystal powder Conforms
Identification The reaction is positive The reaction is postitive
Melting point 191-192°C 191.5℃
Assay 98.5 ~ 102% 99.90%
Loss on drying <0.5% 0.20%
Residuc on ignition <0.1% 0.07%
PH 5.0 ~ 7.5 6.9
Specific rotation +18.5 ~ +20 ° +19.6°
Heavy metals <0.001% 0.0005%
Related substances The any secondary spot <0.5% <0.5%
  total¡Ü0.2% Total <2%
Chloride ¡Ü0.005% 0.00%
Crystallinity Meets the requirements Conforms


Professional Manufacture

We are genuine and legit pharmaceutical manufacturer, all products are produced under GMP conditions according to Standard Operation Procedure(SOP), not from little underground labs or black markets, so the quality is guaranteed.
Competitive advantages
1 High quality with competitive price
  1) Standard: Enterprise Standard
  2) All Purity≥99%
  3) Manufacturer can provide high quality products with factory price.

2 Fast and safe delivery
  1) Sufficient stock & disciplined packing team to make sure prompt and discreet delivery;
  2) Experienced and professional logistic agent can provide various transportation ways;
  3) Parcel can be sent out in 24 hours after payment. Tracking number available;
  4) Customs pass rate ≥99%;
3 After-sale service
  Any questions or problems after receiving the product, please feel free to contact us. Problems would be   solved immediately.
CAS 106650-56-0 Sibutramine Natural Weight Loss Supplements , 100% Guarantee Content
If you are interested in any of our products, or if you have any questions, please feel free to contact me, I will reply you at soonest time.

Contact Person Tina
Email tina@bioproco.com


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